Otoferin
WebApr 28, 2016 · About. PhD in Cellular & Molecular Biology, Manager in Immuno-Oncology, Project Manager. - 15 years of experience in Molecular & Cellular Biology, Virology, Immunology & Vaccines. - Project Management: Management of client relationship, overseeing of project delivery to time and. cost and produce periodic progress reports, … WebLinkedIn and 3rd parties use essential and non-essential cookies to provide, secure, analyze and improve our Services, and to show you relevant ads (including professional and job ads) on and off LinkedIn.Learn more in our Cookie Policy.. Select Accept to consent or Reject to decline non-essential cookies for this use.
Otoferin
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WebThe vestibular system, located in the inner ear, provides information critical for our sense of balance.This system includes five sensory organs – three semicircular canals and two otolith organs called the utricle and saccule – that work together to enable us to determine our position and movement in space. Importantly, the vestibular system also helps to … WebMar 30, 2024 · DB-OTO is being developed in collaboration with Regeneron Pharmaceuticals, Inc and is designed to provide durable, high quality, physiological hearing to individuals with profound, congenital hearing loss caused by mutations of the otoferlin gene. This opinion was adopted by the European Commission (EC).
WebFeb 20, 2015 · otoferlin and GAD65 in both HEK293 and neuronal cells, including SH-SY5Y neuroblastoma and primary rat hippocampus cells, showing a direct interaction between GAD65 and otoferlin’s C2 domains. In primary rat hippocampus cells, otoferlin and GAD65 co-localized in a punctate pattern within the cell body, as well WebJul 29, 2024 · The alignment of otoferlin and otoferlin-related proteins revealed remarkable conservation of amino acids within the human and mouse C2C domains. Mirghomizadeh …
WebNX_Q9HC10 - OTOF - Otoferlin - Function. Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to … WebOTOF is the gene coding for the Otoferlin protein, a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses. OTOF-GT. GENE …
WebMouse monoclonal Otoferlin antibody [13A9]. Validated in Flow Cyt, ICC/IF and tested in Mouse, Human. Cited in 30 publication(s). Independently reviewed in 3 review(s). Immunogen corresponding to…
WebMar 21, 2024 · OTOF (Otoferlin) is a Protein Coding gene. Diseases associated with OTOF include Deafness, Autosomal Recessive 9 and Otof-Related Deafness.Among its related … buy tucker the aa dogWebOct 20, 2006 · The otoferlin C2D domain contains five-aspartic acid residues that are conserved throughout vertebrate species (Figure S3 A) and are predicted to bind Ca 2+ … certified community health worker arizonaWebIdentification of the hair cell soma-1 antigen, HCS-1, as otoferlin. Richardson GP Journal of the Association for Research in Otolaryngology : JARO 11.4 (2010 Dec): 573-86. … buy tub townWebWe found a strong elevation of Cx30 immunoreactivity in the LSO of CaV1.3 KO mice, while Cx43 levels were only slightly increased. In otoferlin KO mice, LSO showed a slight increase in Cx43 as well, whereas Cx30 levels were unchanged. The total number of tracer-coupled cells was unaltered and most networks were anisotropic in both KO strains. buy tube type tree coversWebApr 7, 2024 · Different mutations of the OTOF gene, encoding for otoferlin protein expressed in the cochlear inner hair cells, induces a form of deafness that is the major cause of … certified collision repairWebSep 1, 2009 · Otoferlin is essential for a late step in exocytosis of neurotransmitter at ribbon synapses. In this study, C57BL/6J mice were intraperitoneally injected with gentamicin (100 mg/kg) once a day, the apical coils of organ of Corti were obtained at the 4th day, the 7th day and the 10th day respectively (n = 10/per group), the normal mice without a Gentamicin … buy tub moldWebNov 7, 2016 · Mutations in the otoferlin ( OTOF) gene lead to profound hearing loss in humans. Interestingly, a number of missense otoferlin mutations cause hearing defects … buy tub surround