Web2 feb. 2024 · Deregulated alternative splicing of the endocytic adaptor NUMB resulting in high expression of Exon9in (exon 9-containing) isoforms has been reported in several cancer types. However, the role of Numb isoform expression in tumor progression and the underlying mechanisms remain elusive. Web14 apr. 2024 · NUMB is an endocytic adaptor protein that contains four isoforms (p65, p66, p71 and p72) due to alternative splicing regulation. Here, we show that NUMB exon12 (E12)-skipping isoforms p65/p66 promote epithelial to mesenchymal transition (EMT) and cancer cell migration in vitro, and facilitate cancer metastasis in mice, whereas E12 …
Numb Regulates Glioma Stem Cell Fate and Growth by Altering …
WebWe previously reported that Numb switches from isoforms containing the PTB insertion to isoforms lacking this insertion in neural cultures subjected to stress induced by trophic factor withdrawal. The switch in Numb isoforms enhances the generation of amyloid-β peptide (Aβ), the principle component of senile plaques in Alzheimer's disease (AD). WebMammalian Numb (mNumb) has multiple functions and plays important roles in the regulation of neural development, including maintenance of neural progenitor cells and … robert coote
Anti-NUMB Antibodies Invitrogen
Web18 feb. 2013 · Immunoblot analysis using anti-Numb antibody, which detects all the splice isoforms, also shows a shift in the dominant Numb isoform from Numb-12in (∼71 kD) to Numb-12ex (∼65 kD) during development from E2 to E5 . To determine where Numb-12ex is expressed in the chick neural tube, we analyzed localization of Numb mRNAs. Web23 mrt. 2016 · Because the isoform switch of Numb is important for neuronal development and cancer pathogenesis, it is necessary to understand its underlying mechanism. Our preliminary observation that Rbm4 knockout resulted in abnormal Numb isoform ratios in embryonic brain prompted us to characterize the role of RBM4 in regulating Numb … WebNumb is an evolutionarily conserved protein identified by its ability to control cell fate in the nervous system of Drosophila. Mammals express four isoforms of Numb that differ … robert coover shorts story amazon