WebJul 19, 2016 · Photouncaging of second messengers has been successfully employed to gain mechanistic insight of cellular signaling pathways. One of the most enigmatic processes of ion channel regulation is lipid recognition and lipid-gating of TRPC channels, which represents pivotal mechanisms of cellular Ca2+ homeostasis. Recently, … WebManipulation of lipid pools is a slow process and is usually restricted to soluble lipid-metabolic enzymes or transfer proteins. Caged lipids are highly targeted; however, …
The Road to Quantitative Lipid Biochemistry in Living Cells
WebFeb 1, 2024 · Lipids exert their cellular functions in individual organelles, in some cases on the scale of even smaller, specialized membrane domains. Thus, the experimental capacity to precisely manipulate lipid levels at the subcellular level is crucial for studying lipid-related processes in cell biology. Photo-caged lipid probes which partition into ... WebMay 19, 2016 · Using light to control cellular processes is one of the attractive areas of research. Here, availability of different, light-responsive caged compounds has played a critical role. In this issue of Cell Chemical Biology, Hövelmann et al. (2016) give us an example of how to design and use caged lipids to guide chemotaxis at the single cell level. rome to philly
A Coumarin Triflate Reagent Enables One‐Step Synthesis of Photo‐Caged ...
Web13 hours ago · Exosomes play an important role in the proliferation, adhesion and migration of cancer cells. In this study, we have developed a novel electrochemiluminescence (ECL) sensor based on MoS 2 QDs-MXene heterostructure and Au [email protected] lipid layer to detect exosomal miRNA. MoS 2 QDs-MXene heterostructure had been prepared as the … WebCaged lipids as tools for investigating cellular signaling. @article{Hglinger2014CagedLA, title={Caged lipids as tools for investigating cellular signaling.}, author={Doris H{\"o}glinger and Andr{\'e} Nadler and Carsten Schultz}, journal={Biochimica et biophysica acta}, year={2014}, volume={1841 8}, pages={ 1085-96 } } WebManipulation of lipid pools is a slow process and is usually restricted to soluble lipid-metabolic enzymes or transfer proteins. Caged lipids are highly targeted; however, release of the active lipid is not a reversible process. To bypass some of these issues azobenzene containing lipids have been used as photoswitchable lipids. rome to philadelphia flights