WebOct 1, 2000 · Alfentanil, fentanyl and sufentanil are metabolized in the liver by the enzyme cytochrome P450 3A4. 20 21 Lorazepam, however, is metabolized by hepatic conjugation to glucuronic acid, which is a non‐microsomal reaction and is not affected by changes in cytochrome P450 activity. 22 Furthermore, because alfentanil, fentanyl and sufentanil … WebAbstract. Alfentanil has a different pharmacokinetic and pharmacodynamic profile compared to fentanyl. Alfentanil is approximately five to eight times less potent than fentanyl when given as a single i.v. dose. The onset of alfentanil effect is five to six times more rapid than fentanyl because of a more rapid blood: brain equilibration.
Alfentanil - an overview ScienceDirect Topics
WebAlfentanil can cause muscle rigidity, particularly of the chest wall or jaw; this can be managed by the use of neuromuscular blocking drugs. Pregnancy Respiratory depression and withdrawal symptoms can occur in the neonate if opioid analgesics are used during delivery; also gastric stasis and inhalation pneumonia has been reported in the mother ... Web• Doses of Alfentanil HCl Injection vary depending on circumstances . (see dosing chart, 2.2) • Reduce the dose of Alfentanil HCl Injection in elderly, debilitated and obese patients. (2.4, 2.5) • Reduce the dose of Alfentanil HCl Injection when administered with CNS depressants. (2.6) -----DOSAGE FORMS AND STRENGTHS----- can you create a fake facebook account
HIGHLIGHTS OF PRESCRIBING INFORMATION - Pfizer
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